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Including Females In Basic Research

Including Females In Basic Research

You are here: Home / Archive / Feature Stories / Including Females In Basic Research
Published: October 29, 2017 by RHJ Producer


Before a medication is released to the public, it’s safety and effectiveness must be put to the test. Clinical trials are a key part of this process, but experts say drugs are being proclaimed safe without enough attention on how the impacts differ between men and women.

Dr. Teresa Woodruff, Director of the Women’s Health Research Institute at Northwestern University, suggests the example of the drug Ambien, a common prescription sleep aid that was taken off shelves because of adverse events in women. Even though it was observed that there was a difference in how long it took for the body to clear the drug in men and women, the difference in efficacy was never quantified. The drug was later returned to shelves, but received new labeling instructing women to take smaller doses than men.

Dr. Melina Kibbe, Professor of Surgery at Northwestern University, says this is the first time a drug had explicitly instructed different dosing for men and women, but questions how many more drugs need to be reconsidered. Only one third of research subjects in clinical trials are women and, even if a study has exactly fifty-percent of each sex, issues still remain. “The problem is if you include both sexes but you report the data in aggregate then you won’t know if a drug has say a better effect in men versus women,” Dr. Kibbe explains.

Even before human clinical trials, research is conducted on predominantly male cells and animals, with very little focus on the variable of sex of the subject. Dr. Kathryn Sandburg, Director of the Center for the Study of Sex Differences in Health, Aging and Disease at Georgetown University, says researchers fall victim to the fall belief that there’s less variable in studying male subjects than female because of hormonal cycles. The opposite turns out to be true. Males actually have more variables to control. Recently, there’s been a push to have equality in research subjects, but private pharmaceutical companies are still not required to adhere to these guidelines.


Guest Information:

  • Dr. Teresa Woodruff, Director, Women’s Health Research Institute, Northwestern University
  • Dr. Melina Kibbe, Professor of Surgery, Northwestern University
  • Dr. Kathryn Sandburg, Director, Center for the Study of Sex Differences in Health, Aging & Disease, Georgetown University

Links for more info:

  • Women’s Health Research Institute, Northwestern University
  • Dr. Melina Kibbe
  • Center for the Study of Sex Differences in Health, Aging & Disease, Georgetown University

Program #: 17-44Segment Type: Feature StoriesTopics: Biology| Discrimination and Racism| Gender and Identity| Implicit Bias| Medical Research| Research and Clinical Trials| Research and Development| Research Ethics| Research Funding| Side Effects| Women's HealthGuests: Dr. Kathryn Sandburg| Dr. Melina Kibbe| Dr. Teresa WoodruffInstitutions & Organizations: Center for the Study of Sex Differences in Health, Aging & Disease| Georgetown University| Northwestern University| Women's Health Research Institute
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About RHJ Producer

Since 1992, Radio Health Journal has been bringing listeners useful, verifiable information they can trust and rely on in the fields of medicine, science & technology, research, and the intersection of health & public policy. Both Radio Health Journal and sister show Viewpoints Radio are AURN productions.

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